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butabarbital will lower the extent or result of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. The efficacy of hormonal contraceptives may very well be diminished.butabarbital will lessen the extent or result of glecaprevir/pibrentasvir by af